解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Depression is a debilitating and costly disease for our society, especially in the case of treatment-resistant depression (TRD). Repetitive transcranial magnetic stimulation (rTMS) is an effective adjuvant therapy in treatment-resistant unipolar and non-psychotic depression. It can be applied according to tw...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04255-9
更新日期:2020-04-05 00:00:00
abstract:BACKGROUND:Comprehensive rehabilitation therapy based on traditional Chinese medicine (TCM) has been widely applied in various cancer treatments in China. Thus far, Chinese herbal medicine (CHM) has been shown effective in reducing the adverse effects of chemotherapy and improving the quality of life (QoL) during chemo...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-4162-1
更新日期:2020-04-03 00:00:00
abstract::After publication of our article [1] we have been notified on a mistake in the sample size. ...
journal_title:Trials
pub_type: 已发布勘误
doi:10.1186/s13063-020-04268-4
更新日期:2020-03-30 00:00:00
abstract:BACKGROUND:Plaque psoriasis is a refractory inflammatory skin disease. The common therapies used to treat plaque psoriasis in traditional Chinese medicine (TCM) and western medicine (WM) have distinct characteristics and advantages. Although a combination of TCM and WM therapies, adjusted to the clinical situation, is ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-4209-3
更新日期:2020-03-30 00:00:00
abstract:BACKGROUND:Traumatic brain injury (TBI) is often associated with life-long medical, cognitive, emotional, and behavioral changes. Although long-lasting disabilities are expected, research on effective treatment options in the chronic phase of TBI is scarce. METHODS/DESIGN:This study protocol describes a randomized con...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-4195-5
更新日期:2020-03-27 00:00:00
abstract:BACKGROUND:Non-communicable chronic diseases are linked to behavioral risk factors (including smoking, poor diet and physical inactivity), so effective behavior change interventions are needed to improve population health. However, uptake and impact of these interventions is limited by methodological challenges. We aim...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04235-z
更新日期:2020-03-23 00:00:00
abstract:BACKGROUND:Coronary heart disease (CHD) has become a common cardiovascular disease that seriously threatens the health of people. As reperfusion in the early phase and drug therapy, especially percutaneous coronary intervention (PCI), have become widely used in the clinic, the mortality of acute myocardial infarction i...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-4208-4
更新日期:2020-03-20 00:00:00
abstract:BACKGROUND:Recommendations for good clinical practice have been reported to be difficult to apply in real life by primary care clinicians. This could be because the clinical trials at the origin of the guidelines are based on explanatory trials, conducted under ideal conditions not reflecting the reality of primary car...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-4215-5
更新日期:2020-03-19 00:00:00
abstract:BACKGROUND:Understanding why people take part in health research is critical to improve research efficiency and generalisability. The aim of this overview of systematic reviews was to identify psychosocial determinants of research participation and map them to psychological theory and empirical recruitment research, to...
journal_title:Trials
pub_type: 杂志文章,评审
doi:10.1186/s13063-020-4197-3
更新日期:2020-03-12 00:00:00
abstract:BACKGROUND:The aim of this study is to demonstrate that capecitabine metronomic chemotherapy is non-inferior to capecitabine conventional chemotherapy as maintenance treatment, in patients who have responded to 16-18 weeks first-line chemotherapy in metastatic colorectal cancer (mCRC). METHODS:The study design is a pr...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-4194-6
更新日期:2020-03-06 00:00:00
abstract:BACKGROUND:Single-sided deafness (SSD) describes the presence of a unilateral severe to profound sensorineural hearing loss. SSD disrupts spatial hearing and understanding speech in background noise. It has functional, psychological and social consequences. Potential options for rehabilitation include hearing aids and ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-4094-9
更新日期:2020-03-04 00:00:00
abstract:BACKGROUND:In cardiac surgery with cardiopulmonary bypass (CPB), large amounts of fluids are administered. CPB priming with crystalloid solution causes marked hemodilution and fluid extravasation. Colloid solutions may reduce fluid overload because they have a better volume expansion effect than crystalloids. The Europ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-4160-3
更新日期:2020-02-28 00:00:00
abstract:BACKGROUND:Emerging evidence has shown that vitamin D and magnesium have anti-inflammatory and anti-depressant effects. Dietary intake of magnesium is associated with reduced body mass index, waist circumference, body fat percentage, as well as inflammatory biomarkers and depressive symptoms. Vitamin D deficiency has b...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-4122-9
更新日期:2020-02-26 00:00:00
abstract:BACKGROUND:Approximately 40% of the newly diagnosed patients with advanced ovarian cancer are aged 70 years or older. Standard treatment for advanced disease consists of cytoreductive surgery and combination chemotherapy. In older patients, standard treatment is often withheld or prematurely stopped due to suspected fr...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-4157-y
更新日期:2020-02-22 00:00:00
abstract:BACKGROUND:Intraoperative driving pressure (ΔP) is associated with development of postoperative pulmonary complications (PPC). When tidal volume (VT) is kept constant, ΔP may change according to positive end-expiratory pressure (PEEP)-induced changes in lung aeration. ΔP may decrease if PEEP leads to a recruitment of c...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-4075-z
更新日期:2020-02-18 00:00:00
abstract:BACKGROUND:Unhealthy alcohol use is a leading cause of morbidity and mortality among young people, including university students. Delivering secondary prevention interventions against unhealthy alcohol use is challenging. Information technology has the potential to reach large parts of the general population. The prese...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-4145-2
更新日期:2020-02-17 00:00:00
abstract:BACKGROUND:Dementia is a neurological condition that affects the cognitive and functional ability of the brain and is the leading cause of disability among those aged 65 years and above. More effective ways to manage dementia symptoms are needed because current treatment options (antidepressants and antipsychotics) can...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-4085-x
更新日期:2020-02-14 00:00:00
abstract:BACKGROUND:This study is a part of a series of two clinical trials. We consider diabetic polyneuropathy (DPN), a common chronic and progressive complication of diabetes mellitus that has several impacts on individuals' foot health and quality of life. Based on the current trends of self-monitoring and self-care, provid...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-4115-8
更新日期:2020-02-13 00:00:00
abstract::After publication of our article [1] the authors have notified us that one of the names has been incorrectly spelled. ...
journal_title:Trials
pub_type: 杂志文章,已发布勘误
doi:10.1186/s13063-020-4107-8
更新日期:2020-02-12 00:00:00
abstract:BACKGROUND:Impulsivity and compulsivity are related to emotional and social maladjustment and often underlie psychiatric disorders. Recently, alterations in microbiota composition have been shown to have implications for brain development and social behavior via the microbiota-gut-brain axis. However, the exact mechani...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-4040-x
更新日期:2020-02-11 00:00:00
abstract:BACKGROUND:Necrotizing enterocolitis (NEC) is the leading cause of death among preterm infants born at < 30 weeks' gestation. The incidence of NEC is reduced when infants are fed human milk. However, in many neonatal intensive care units (NICUs), it is standard practice to freeze and/or pasteurize human milk, which dea...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3981-4
更新日期:2020-02-11 00:00:00
abstract:BACKGROUND:Non-inferiority trials are increasingly used to evaluate new treatments that are expected to have secondary advantages over standard of care, but similar efficacy on the primary outcome. When designing a non-inferiority trial with a binary primary outcome, the choice of effect measure for the non-inferiority...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-4070-4
更新日期:2020-02-06 00:00:00
abstract:BACKGROUND:Diabetes mellitus is associated with risk of sudden sensorineural hearing loss (SSNHL). Systemic and intratympanic corticosteroids are the two primary treatments for SSNHL in patients with diabetes mellitus. The benefit of intratympanic compared to systemic treatment is the reduced systemic steroid exposure ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-4077-x
更新日期:2020-02-03 00:00:00
abstract:BACKGROUND:Incurable cancer does not only affect patients, it also affects the lives of their partners. Many partners take on caregiving responsibilities. The burden of these caregiving tasks are often associated with physical, psychological, and social difficulties and many partners have unmet supportive care needs. O...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-4037-5
更新日期:2020-01-31 00:00:00
abstract:BACKGROUND:Preterm birth accounts for 75% of perinatal deaths and more than 50% of long-term neurological disabilities. For a singleton pregnancy, progesterone treatment is effective in prevention of preterm birth in women with an asymptomatic short cervix or a history of preterm birth. However, a large proportion of p...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-4067-z
更新日期:2020-01-30 00:00:00
abstract:BACKGROUND:In Nepal, the burden of noncommunicable, chronic diseases is rapidly rising, and disproportionately affecting low and middle-income countries. Integrated interventions are essential in strengthening primary care systems and addressing the burden of multiple comorbidities. A growing body of literature support...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-4063-3
更新日期:2020-01-29 00:00:00
abstract:BACKGROUND:Hysterosalpingography (HSG) is an accepted radiologic diagnostic modality for initial infertility workup, and is generally considered uncomfortable and painful. However, the management of pain related to HSG remains inefficient. As an emerging nonpharmacologic and noninvasive pain control strategy, virtual r...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-019-4023-y
更新日期:2020-01-20 00:00:00
abstract:BACKGROUND:Youth depression is highly prevalent and is related to impairments in academic, social and behavioural functioning. Evidence-based treatments are available, but many young people do not respond or sufficiently recover with first-line options, and a significant proportion experience relapse. Consequently, the...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-019-4036-6
更新日期:2020-01-14 00:00:00
abstract:BACKGROUND:Equipoise and role conflict have been previously identified as important factors in professionals' engagement with trials, inducing behaviours which can impact on recruitment. We explored these phenomena as potential explanations for the low levels of involvement of teenagers and young adults (TYA) with canc...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3942-y
更新日期:2020-01-10 00:00:00
abstract:BACKGROUND:Asylum seekers and refugees are at great risk for developing mental disorders. Afghan refugees are a particularly vulnerable group with a low average education and mental health literacy level. Traumatic experiences and hardship before and during migration are predictive of mental health problems. However, p...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-019-3839-9
更新日期:2020-01-09 00:00:00
abstract:BACKGROUND:Post-dural puncture headache (PDPH) is one of the most common complications of neuraxial anaesthesia. It limits patients' general activity and increases the length of hospital stays and the use of care. It is particularly disabling during the postpartum period, when mothers have to take care of their child. ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-4015-y
更新日期:2020-01-08 00:00:00
abstract:BACKGROUND:School-based comprehensive sexual health education can improve adolescent health outcomes, and web-based programs are a promising approach to overcoming challenges associated with teacher-led formats by ensuring that students receive content that is consistent, unbiased, and medically accurate. However, many...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3992-1
更新日期:2020-01-08 00:00:00
abstract:BACKGROUND:Given the complex nature of opioid addiction treatment and the rising number of available opioid substitution and antagonist therapies (OSAT), there is no 'gold standard' measure of treatment effectiveness, and each successive trial measures a different set of outcomes which reflect success in arbitrary or o...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3995-y
更新日期:2020-01-06 00:00:00
abstract:BACKGROUND:The prevalence of central obesity is constantly increasing, and visceral fat is associated with increased production of inflammatory factors and metabolic risk factors. Lutein might retard the development of metabolic disease through its antioxidant and anti-inflammatory properties. Furthermore, epidemiologi...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3998-8
更新日期:2020-01-06 00:00:00
abstract:BACKGROUND:Process evaluations are an important component in the interpretation and understanding of outcomes in trials. The Online Remote Behavioural Intervention for Tics (ORBIT) study is a randomized controlled trial evaluating the effectiveness of an Internet-delivered behavioural intervention (called BIP TIC) comp...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-019-3974-3
更新日期:2020-01-02 00:00:00
abstract:BACKGROUND:HIV-related stigma significantly impacts HIV care engagement, including in prevention of mother-to-child transmission of HIV (PMTCT) programs. Maisha is a stigma-based counseling intervention delivered during the first antenatal care (ANC) visit, complementing routine HIV counseling and testing. The goal of ...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-019-3933-z
更新日期:2019-12-30 00:00:00
abstract:BACKGROUND:Home parenteral nutrition (HPN) is a life-preserving therapy for patients with chronic intestinal failure (CIF) indicated for patients who cannot achieve their nutritional requirements by enteral intake. Intravenously administered lipid emulsions (ILEs) are an essential component of HPN, providing energy and...
journal_title:Trials
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s13063-019-3994-z
更新日期:2019-12-30 00:00:00
abstract:BACKGROUND:High-protein diets and total diet replacements are becoming increasingly popular for weight regulation; however, further research is needed to elucidate their impact on the physiology of body weight regulation. The aim of this inpatient metabolic balance study is to compare the impact of a high-protein total...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3950-y
更新日期:2019-12-27 00:00:00
abstract:BACKGROUND:There is a high prevalence of pain and post-traumatic symptoms among refugees and feasible interventions to manage these are needed. However, knowledge about the effect of physiotherapy and psychological group interventions among refugees is scarce. Our aim is to determine whether two different interventions...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3919-x
更新日期:2019-12-27 00:00:00
abstract:BACKGROUND:Current international guidelines recommend the use of a daily topical exit-site antimicrobial to prevent peritoneal dialysis (PD)-related infections. Although nonantibiotic-based therapies are appealing because they may limit antimicrobial resistance, no controlled trials have been conducted to compare topic...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3953-8
更新日期:2019-12-19 00:00:00